Emergence of mupirocin resistance in multiresistant Staphylococcus aureus clinical isolates belonging to Brazilian epidemic clone III::B:A

• Published in: Journal of medical microbiology Vol. 48; no. 3; pp. 303 - 307
• Main Authors: RAMOS, R.L.B, TEIXEIRA, L.A, ORMONDE, L.R, SIQUEIRA, P.L.A, SANTOS, M.S, MARANGONI, D, FIGUEIREDO, A.M.S
• Format: Journal Article
• Language: English
• Published: England Soc General Microbiol 01-03-1999
• Subjects: Anti-Bacterial Agents - pharmacology; Brazil; Cross Infection - microbiology; Disease Outbreaks; DNA, Bacterial - analysis; Drug Resistance, Microbial - genetics; Drug Resistance, Multiple; Humans; Methicillin Resistance; Microbial Sensitivity Tests; Mupirocin - pharmacology; Physical Chromosome Mapping; Staphylococcal Infections - microbiology; Staphylococcus aureus - drug effects; Staphylococcus aureus - genetics; Staphylococcus aureus - isolation & purification; Brazil
• ISSN: 0022-2615; 1473-5644
• DOI: 10.1099/00222615-48-3-303

* Universidade Federal do Rio de Janeiro, Instituto de Microbiologia Prof. Paulo de Góes, Laboratório de Biologia Molecular de Bactérias, Centro de Ci ncias da Saúde, Bloco I, Cidade Universitária, Rio de Janeiro, RJ 21941.590, Brazil
The Rockefeller University, 1230 York Avenue 10021, New York, NY, USA
Instituto de Puericultura Martagão Gesteira, Universidade Federal do Rio de Janeiro
* Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Brazil
Corresponding author: Dr A.M.S. Figueiredo (e-mail: [e-mail]).
Received March 3, 1998
Revision received June 26, 1998.
Mupirocin is a topical antimicrobial agent that has been sucessfully used to eradicate methicillin-resistant Staphyiococcus aureus from the anterior nares and other sites of patients and health care personnel. This report describes the acquisition of a novel mupirocin resistance gene ( ileS ) by an epidemic MRSA clone that is geographically widespread in Brazil.