Isolation of two new trichorzin PA derivatives, trichorzin PA X and XI, from the terrestrial fungus Trichoderma harzianum IFM 66736

Isolation of two new trichorzin PA derivatives, trichorzin PA X and XI, from the terrestrial fungus Trichoderma harzianum IFM 66736

[Display omitted] Two new octadeca-peptibols, trichorzin PA X and XI (1 and 2), were isolated from the fungus Trichoderma harzianum IFM 66736, which was obtained from the soil collected from the Aobanomori Park in Chiba City, Japan. The structures of the compounds were elucidated using spectral stud...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 121; p. 154488
Main Authors: Hara, Yasumasa, Manome, Teruhisa, Suehiro, Wataru, Harada, Shinji, Yamagishi, Yoshikazu, Takaya, Akiko, Ogra, Yasumitsu, Ishibashi, Masami
Format: Journal Article
Language:English
Published: Elsevier Ltd 17-05-2023
Subjects:
Cancer cell line
Cytotoxicity
Peptibol
Trichoderma harzianum
Trichoderma harzianum
Peptibol
Cytotoxicity
Cancer cell line
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Summary:[Display omitted] Two new octadeca-peptibols, trichorzin PA X and XI (1 and 2), were isolated from the fungus Trichoderma harzianum IFM 66736, which was obtained from the soil collected from the Aobanomori Park in Chiba City, Japan. The structures of the compounds were elucidated using spectral studies, X-ray crystallographic analysis, and MS/MS analysis. Compounds 1 and 2 showed cytotoxicity against human colon cancer cell lines HCT116.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2023.154488