Metal-organic frameworks based surface-enhanced Raman spectroscopy technique for ultra-sensitive biomedical trace detection

• Published in: Nano research Vol. 16; no. 2; pp. 2968 - 2979
• Main Authors: Zhang, Yuna, Xue, Cuili, Xu, Yuli, Cui, Shengsheng, Ganeev, Alexander A., Kistenev, Yury V., Gubal, Anna, Chuchina, Victoria, Jin, Han, Cui, Daxiang
• Format: Journal Article
• Language: English
• Published: Beijing Tsinghua University Press 2023
• Subjects: Atomic/Molecular Structure and Spectra; Biomedicine; Biotechnology; Chemistry and Materials Science; Condensed Matter Physics; Materials Science; Mini Review; Nanotechnology; metal-organic framework (MOF); synthesis strategy; surface-enhanced Raman scattering (SERS); biomedical trace detection
• ISSN: 1998-0124; 1998-0000
• DOI: 10.1007/s12274-022-4914-1

Metal-organic frameworks (MOFs) have attracted widespread interest due to their unique and unprecedented advantages in microstructures and properties. Besides, surface-enhanced Raman scattering (SERS) technology has also rapidly developed into a powerful fingerprint spectroscopic technique that can provide rapid, non-invasive, non-destructive, and ultra-sensitive detection, even down to single molecular level. Consequently, a considerable amount of researchers combined MOFs with the SERS technique to further improve the sensing performance and broaden the applications of SERS substrates. Herein, representative synthesis strategies of MOFs to fabricate SERS-active substrates are summarized and their applications in ultra-sensitive biomedical trace detection are also reviewed. Besides, relative barriers, advantages, disadvantages, future trends, and prospects are particularly discussed to give guidance to relevant researchers.