Tracking stem cells in tissue-engineered organs using magnetic nanoparticles

The use of human stem cells (SCs) in tissue engineering holds promise in revolutionising the treatment of numerous diseases. There is a pressing need to comprehend the distribution, movement and role of SCs once implanted onto scaffolds. Nanotechnology has provided a platform to investigate this thr...

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Bibliographic Details
Published in:	Nanoscale Vol. 5; no. 23; p. 11362
Main Authors:	Hachani, Roxanne, Lowdell, Mark, Birchall, Martin, Thanh, Nguyen Thi Kim
Format:	Journal Article
Language:	English
Published:	England 07-12-2013
Subjects:	Cell Tracking Contrast Media - chemistry Contrast Media - metabolism Ferric Compounds - chemistry Gadolinium - chemistry Humans Magnetic Resonance Imaging Magnetite Nanoparticles - chemistry Receptors, Cell Surface - chemistry Receptors, Cell Surface - metabolism Stem Cell Transplantation Stem Cells - cytology Stem Cells - metabolism Tissue Engineering
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Summary:	The use of human stem cells (SCs) in tissue engineering holds promise in revolutionising the treatment of numerous diseases. There is a pressing need to comprehend the distribution, movement and role of SCs once implanted onto scaffolds. Nanotechnology has provided a platform to investigate this through the development of inorganic magnetic nanoparticles (MNPs). MNPs can be used to label and track SCs by magnetic resonance imaging (MRI) since this clinically available imaging modality has high spatial resolution. In this review, we highlight recent applications of iron oxide and gadolinium based MNPs in SC labelling and MRI; and offer novel considerations for their future development.
ISSN:	2040-3372
DOI:	10.1039/c3nr03861k