Doppler Resistivity and Cerebral Small Vessel Disease: Hemodynamic Structural Correlation and Usefulness for the Etiological Classification of Acute Ischemic Stroke

• Published in: Journal of stroke and cerebrovascular diseases Vol. 27; no. 12; pp. 3425 - 3435
• Main Authors: de la Cruz-Cosme, Carlos, Dawid-Milner, Marc Stefan, Ojeda-Burgos, Guillermo, Gallardo-Tur, Alejandro, Segura, Tomás
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-12-2018
• Subjects: Aged; Brain Ischemia - diagnostic imaging; Brain Ischemia - etiology; Carotid Artery, Internal - diagnostic imaging; cerebral small vessel diseases; Cerebral Small Vessel Diseases - diagnostic imaging; Cerebral Small Vessel Diseases - etiology; Cerebrovascular Circulation; Female; Hemodynamics; Humans; Male; Microangiopathy; Middle Aged; Prospective Studies; Stroke - diagnostic imaging; Stroke - etiology; Stroke, lacunar; Ultrasonography, Doppler; Ultrasonography, Doppler, Transcranial; Stroke, lacunar; cerebral small vessel diseases; Ultrasonography, Doppler; Microangiopathy
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2018.08.001

Lacunar stroke is defined as an <1.5 cm diameter infarct located in the territory of a perforating artery, that is not accessible for direct study using conventional imaging techniques. Diagnosis requires exclusion of other causes. It usually occurs in the context of chronic cerebral small vessel disease, which can be suspected during the neurosonography study in the form of high pulsatility [PI] or resistance index [RI]. Clinical research was performed to confirm that PI and RI correlate with cerebral small vessel lesion burden and to determine whether these parameters are useful for supporting a lacunar origin (LO) in acute stroke.
We prospectively recorded internal carotid artery resistivity and the Fazekas score for all patients with acute ischemic stroke who met inclusion but not exclusion criteria over a 6-month period.
The study population comprised 74 patients. A correlation was observed between the Fazekas score and resistivity. Both parameters predicted a LO, with an area under the curve of .78 and .696, respectively. The optimal cut-offs were PI = .96/RI = .58 for screening (sensitivity, 96%) and PI = 1.46/RI = .83 for confirmation (specificity, 89%).
Doppler ultrasound is a useful technique for determining the LO of acute stroke.