Covalent and noncovalent interactions of coordination compounds with DNA: An overview

• Published in: Journal of inorganic biochemistry Vol. 225; p. 111624
• Main Authors: Andrezálová, Lucia, Országhová, Zuzana
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-12-2021
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - therapeutic use; Binding constant; Coordination Complexes - chemistry; Coordination Complexes - metabolism; Coordination Complexes - therapeutic use; Coordination compound; Cytotoxicity; DNA - chemistry; DNA - metabolism; DNA interactions; Humans; Intercalating Agents - chemistry; Intercalating Agents - metabolism; Intercalating Agents - therapeutic use; Ligands; Metal complex; Metals, Heavy - chemistry; Neoplasms - drug therapy; Static Electricity; Transition metals; Transition metals; Im; DMSO; Binding constant; bip; Cytotoxicity; dach; THA; PPO; L-arg; NAMI-A; tpphz; DNA interactions; KP1019; phen; IC50; chrysi; bpm; SCLC; Coordination compound; dpq; NSCLC; dppn; BBR3464; Metal complex; en; bpy; NAMI; bidppz; glygly; PyTA; Mephen; PzTA; SI-PPCs; MMR; PPCs; ACRAMTU; DPE; dppz; DHA; PBIP; Me2bpy; vdW forces; Ind
• ISSN: 0162-0134; 1873-3344
• DOI: 10.1016/j.jinorgbio.2021.111624

Deoxyribonucleic acid plays a central role in crucial cellular processes, and many drugs exert their effects through binding to DNA. Since the discovery of cisplatin and its derivatives considerable attention of researchers has been focused on the development of novel anticancer metal-based drugs. Transition metal complexes, due to their great diversity in size and structure, have a big potential to modify DNA through diverse types of interactions, making them the prominent class of compounds for DNA targeted therapy. In this review we describe various binding modes of metal complexes to duplex DNA based on covalent and noncovalent interactions or combination of both. Specific examples of each binding mode as well as possible cytotoxic effects of metal complexes in tumor cells are presented.
In this review, we describe the reversible and irreversible binding modes of transition metal complexes to duplex DNA. In vitro and in vivo anticancer activities of metal complexes are also discussed. [Display omitted]
•Irreversible and reversible binding of metal complexes to DNA duplex.•Dual binding modes: combinations of irreversible and reversible binding modes.•Antiproliferative/cytotoxic activity of metal complexes.