Early‐ and late‐onset postpartum depression exhibit distinct associated factors: the IGEDEPP prospective cohort study

• Published in: BJOG : an international journal of obstetrics and gynaecology Vol. 128; no. 10; pp. 1683 - 1693
• Main Authors: Tebeka, S, Le Strat, Y, Mandelbrot, L, Benachi, A, Dommergues, M, Kayem, G, Lepercq, J, Luton, D, Ville, Y, Ramoz, N, Mullaert, J, Dubertret, C, Bertin, Emmanuelle, Bourneuf, Cecile, Colombe, Jeanne, Couppa, Laura, Georges, Fanny, Hebbache, Celine, Le Bars, Marie, Madhavi, Julie Guiot, Parent, Cindy, de Premorel, Alix
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01-09-2021
• Subjects: Childhood trauma; Children; Cohort analysis; depression; Mental depression; Mental disorders; Postpartum; Postpartum depression; Pregnancy; psychiatric history; Risk factors; Sociodemographics; stressful life events; Trauma; Womens health; postpartum; depression; Childhood trauma; stressful life events; psychiatric history
• ISSN: 1470-0328; 1471-0528
• DOI: 10.1111/1471-0528.16688

Objective
To identify risk factors for early‐ and late‐onset postpartum depression (PPD) among a wide range of variables, including sociodemographic characteristics, childhood trauma, stressful life events during pregnancy and history of personal and family psychiatric disorders, and to assess the contribution of each risk factor.
Design
Nested case–control study in a prospective longitudinal cohort study.
Setting
Eight maternity departments in the Paris metropolitan area, France.
Sample
A cohort of 3310 women with deliveries between November 2011 and June 2016.
Methods
Cases were women with early‐ or late‐onset PPD. Controls were women without depression during pregnancy or the postpartum period. Logistic regression adjusted on sociodemographic variables was performed for each outcome and a multivariable model was proposed based on a stepwise selection procedure.
Main outcome measures
Early‐ and late‐onset PPD assessed at 2 months and 1 year postpartum, respectively.
Results
Stressful life events during pregnancy have a dose–response relationship with both early‐ and late‐onset PPD.
Conclusions
Early‐ and late‐onset PPD presented distinct patterns of determinants. These results have important consequences in terms of prevention and specific care.
Tweetable
Early‐ and late‐onset postpartum depression are associated with stressful life events and psychiatric history.
Tweetable
Early‐ and late‐onset postpartum depression are associated with stressful life events and psychiatric history.