Use of Anorganic Bovine‐Derived Hydroxyapatite Matrix/Cell‐Binding Peptide (P‐15) in the Treatment of Class II Furcation Defects: A Clinical and Radiographic Study in Humans

• Published in: Journal of periodontology (1970) Vol. 78; no. 12; pp. 2277 - 2283
• Main Authors: Eto, Ana L., Joly, Julio C., Jeffcoat, Marjorie, de Araújo, Ney S., de Araújo, Vera C., Cury, Patricia R.
• Format: Journal Article
• Language: English
• Published: Chicago, IL American Academy of Periodontology 01-12-2007
• Subjects: Adult; Animals; Biological and medical sciences; Bone Regeneration; Cattle; Clinical trial; Collagen - therapeutic use; Dentistry; Double-Blind Method; Durapatite - therapeutic use; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; furcation defect; Furcation Defects - diagnostic imaging; Furcation Defects - etiology; Furcation Defects - surgery; Humans; Male; Medical sciences; Middle Aged; Non tumoral diseases; Otorhinolaryngology. Stomatology; Peptide Fragments - therapeutic use; periodontal regeneration; periodontitis; Periodontitis - complications; Radiography, Bitewing; Statistics, Nonparametric; Subtraction Technique; Surgical Flaps; Treatment Outcome; Human; Radiodiagnosis; Bovine; Peptides; Stomatology; Use; Exploration; Hydroxyapatite; Dentistry; Radiography; Regeneration; Periodontal disease; Vertebrata; periodontal regeneration; Mammalia; Treatment; Periodontitis; Clinical trial; Artiodactyla; Cell; Ungulata; Furcation defect
• ISSN: 0022-3492; 1943-3670
• DOI: 10.1902/jop.2007.070234

Background: This study compared clinical and radiographic findings for the treatment of Class II furcation defects in human mandibular molars using anorganic bovine‐derived hydroxyapatite matrix (ABM)/cell‐binding peptide (P‐15) or open flap debridement (OFD).
Methods: Twelve subjects showing two comparable Class II furcation defects in their mandibular molars were enrolled. The defects in each subject were assigned randomly to the test (ABM/P‐15) or the control (OFD) group. Clinical measurements and standardized radiographs were taken at baseline and 6 to 7 months after surgery.
Results: There were no statistically significant differences between the test and control groups for any clinical or radiographic parameter (P >0.05). On comparing the baseline and final measurements, the gain in horizontal clinical attachment level and reduction in gingival recession were significant only in the test group (P ≤0.02), whereas the gain in the vertical clinical attachment level was significant in both groups (P ≤0.04). In the test group, four of 12 sites showed complete closure, and five showed partial closure; in the control group, three defects showed complete closure, and four showed partial closure (P = 0.42). Subtraction radiography revealed similar gains in bone height and increases in mean bone density with both treatments (P >0.05).
Conclusions: ABM/P‐15 yielded favorable results in the treatment of Class II furcation defects over a 6‐month evaluation period; however, there was no difference compared to OFD. Further studies using a larger sample size are needed to confirm the present findings.