Organocatalytic Asymmetric Michael Addition of Ketones to α, β-Unsaturated Nitro Compounds

Organocatalytic Asymmetric Michael Addition of Ketones to α, β-Unsaturated Nitro Compounds

An organic catalyst “(R, R)-1,2-diphenylethylenediamine(DPEN) derivative’’ was devel-oped as a chiral bifunctional organocatalyst and applied for asymmetric Michael additions of aromatic ketones to trans-β-nitroalkene compounds under neutral conditions. The isopropyl-subs-tituted thiourea catalyst i...

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Bibliographic Details
Published in:Catalysts Vol. 10; no. 6; p. 618
Main Authors: Jae Ho Shim, Si Hun Nam, Byeong-Seon Kim, Deok-Chan Ha
Format: Journal Article
Language:English
Published: MDPI AG 01-06-2020
Subjects:
asymmetric
enantioselectivity
organocatalyst
thiourea catalyst
yield
Online Access:Get full text
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Summary:An organic catalyst “(R, R)-1,2-diphenylethylenediamine(DPEN) derivative’’ was devel-oped as a chiral bifunctional organocatalyst and applied for asymmetric Michael additions of aromatic ketones to trans-β-nitroalkene compounds under neutral conditions. The isopropyl-subs-tituted thiourea catalyst in neutral condition provides high chemical yield and enantioselectivities (ee) (up to 96% yield, 98% ee).
ISSN:2073-4344
DOI:10.3390/catal10060618