Effect of 2-n-heptyl-4-hydroxyquinoline N-oxide on proton permeability of the mitochondrial membrane

The respiratory-chain inhibitor 2-n-heptyl-4-hydroxyquinoline N-oxide catalyses transmembrane proton transport driven by a pH gradient in isolated rat liver mitochondria. This effect explains the apparent blockade of net proton translocation by this compound in mitochondria respiring with ferrocyani...

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Bibliographic Details
Published in:	Biochemical journal Vol. 186; no. 2; pp. 637 - 639
Main Authors:	Krab, K, Wikström, M
Format:	Journal Article
Language:	English
Published:	England 15-02-1980
Subjects:	Animals Cell Membrane Permeability - drug effects Hydroxyquinolines - pharmacology Intracellular Membranes - drug effects Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Protons Rats
Online Access:	Get full text
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Summary:	The respiratory-chain inhibitor 2-n-heptyl-4-hydroxyquinoline N-oxide catalyses transmembrane proton transport driven by a pH gradient in isolated rat liver mitochondria. This effect explains the apparent blockade of net proton translocation by this compound in mitochondria respiring with ferrocyanide as described by Papa, Lorusso, Guerrieri, Boffoli, Izzo & Capuano [(1977) in Bioenergetics of Membranes (Packer, Papageorgiu & Trebst, eds.), pp. 377-388, Elsevier/North-Holland, Amsterdam] and by Lorusso, Capuano, Boffoli, Stefanelli & Papa [(1979) Biochem. J. 182, 133-147].
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0264-6021 0306-3283 1470-8728
DOI:	10.1042/bj1860637