Pain after tonsillectomy: effectiveness of current guidelines?

• Published in: European archives of oto-rhino-laryngology Vol. 275; no. 1; pp. 281 - 286
• Main Authors: Walrave, Y., Maschi, C., Bailleux, S., Falk, A. T., Hayem, C., Carles, M., De la Brière, F.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 2018
• Subjects: Head and Neck Surgery; Medicine; Medicine & Public Health; Miscellaneous; Neurosurgery; Otorhinolaryngology; Analgesia; Observational study; Postoperative hemorrhage; Pain; Tonsillectomy; Non-steroidal/therapeutic use; Tramadol; Ibuprofen; Postoperative/drug therapy; Children; Prospective studies; Anti-inflammatory agents
• ISSN: 0937-4477; 1434-4726
• DOI: 10.1007/s00405-017-4788-0

Background
Tonsillectomy is one of the most common major surgical procedures performed in children. In 2013, the use of codeine in children was severely restricted. French guidelines for treating tonsillectomy’s postoperative pain at home have been reconsidered
Objective
The aim of our study was to measure effectiveness and safety of two schedules: acetaminophen + ibuprofen (A + I) and acetaminophen + tramadol (A + T) in children who underwent tonsillectomy.
Setting and patients
We undertook a 1 year prospective and observational single-center study. All children who underwent tonsillectomy were eligible. The choice of the regimen, A + I group or A + T group, was left for the anesthesiologist in charge, done during the pre-anesthetic assessment. After hospital discharge, parents had to give systematically A + I or A + T, 4 times a day during 5 days and then acetaminophen alone for the next 5 days The primary endpoint was the home pain assessed using Parents’ Postoperative Pain Measurement Short Form (PPPM-SF) scale. Secondary endpoints were the rate of further hospitalization and/or surgery due to tonsillectomy-related adverse events.
Results
Over the study period, 342 tonsillectomies were performed. The return rate of PPPM-SF scales was 58%. Two hundred patients were analyzed. The median age was 4 [3; 5.2] years and was lower in group A + I (4 [3; 5]; 5 [4; 7];
p
 < 0.0001). PPPM-SF scores were greater than or equal to 3 in both groups during the first 6 postoperative days. The mean decrease of PPPM-SF score over time was higher in group A + I than in group A + T (
p
 = 0.007). Readmission rate was significantly higher in group A + T (A + I: 0; A + T: 7;
p
 = 0.002) as the rate of reoperation for bleeding (A + I: 0; A + T: 3;
p
 = 0.049).
Conclusion
Home pain management after tonsillectomy should be improved. In clinical practice, A + I seems at least as effective as the combination A + T, without increasing readmission and/or additional surgery for bleeding.