Effect of Adaptation to Graduated Physical Exercises on the Function of the Rat Myocardium

• Published in: Neurophysiology (New York) Vol. 41; no. 1; pp. 37 - 42
• Main Authors: Talanov, S. A, Buryi, V. A, Sagach, V. F
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01-02-2009; Springer US; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Cardiology; contractile activity; Exercise; graduated physical exercises; Heart; ischemia-reperfusion; myocardium; Neurosciences; reaction of Frank-Starling; Rodents; myocardium; contractile activity; ischemia-reperfusion; graduated physical exercises; reaction of Frank–Starling
• ISSN: 0090-2977; 1573-9007
• DOI: 10.1007/s11062-009-9074-3

On isolated hearts obtained from control rats and rats subjected to regular physical exercises (forced swimming) during 6 weeks, we studied the contractile activity of the heart, resistance of the myocardium to ischemia/reperfusion-induced injuries, as well as the dependence of the developed and end-diastolic pressures in the aortic ventricle (AV) on the strain of the myocardium (by means of a dosed increase in the volume of a polyethylene reservoir inserted into the ventricle). It was demonstrated that adaptation to regular graduated physical exercises exerts a positive effect on the functional state of the AV myocardium and its contractile function. This was manifested in intensification of the contractile activity of the myocardium, a decrease in its oxygen “job cost,” and an increase in the resistance to injuries induced by ischemia-reperfusion. In addition, regular physical trainings led to an increase in the resistance of the AV myocardium to the strain. In trained rats, the plateau of the Frank-Starling plot was significantly greater than that in control animals, while the rigidity of the AV myocardium was significantly lower.