Apolipoprotein A5-1131T>C polymorphism, but not APOE genotypes, increases susceptibility for dyslipidemia in children and adolescents

• Published in: Molecular biology reports Vol. 38; no. 7; pp. 4381 - 4388
• Main Authors: Brito, D. D. V., Fernandes, A. P., Gomes, K. B., Coelho, F. F., Cruz, N. G., Sabino, A. P., Cardoso, J. E., Figueiredo-Filho, P. P., Diamante, R., Norton, C. R., Sousa, M. O.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-10-2011; Springer Nature B.V
• Subjects: Adolescent; Animal Anatomy; Animal Biochemistry; Apolipoprotein A-V; Apolipoproteins; Apolipoproteins A - genetics; Apolipoproteins E - genetics; Biomedical and Life Sciences; Child; Children & youth; Demography; Dyslipidemias - blood; Dyslipidemias - genetics; Female; Gene Frequency - genetics; Genetic Association Studies; Genetic Predisposition to Disease; Genotype & phenotype; Histology; Humans; Life Sciences; Lipids; Lipids - blood; Male; Molecular biology; Morphology; Polymorphism; Polymorphism, Single Nucleotide - genetics; Teenagers; Young Adult; Adolescents; Dyslipidemia; Children
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-010-0565-5

Apolipoprotein A5 (APOA5) and apolipoprotein E (APOE) play important roles in the metabolism of cholesterol and triglycerides. The aim of this study was to determine the allelic and genotypic distributions of the
APOA5
-
1131T
>
C
(rs 662799) and the
APOE
Hha
I polymorphisms and to identify the association of both individual and combined
APOA5
–
APOE
genetic variants and the risk for dyslipidemia in children and adolescents. We genotyped 53 dyslipidemic and 77 normolipidemic individuals. The total cholesterol, triglycerides and HDL cholesterol were determined enzymatically. For
APOA5
polymorphism, the presence of the allele C confers an individual risk for dyslipidemia (OR = 2.38, 95% CI = 1.15–4.89;
P
 = 0.018). No significant differences were observed for lipid parameters among the
APOA5
groups, except for a higher value of HDLc (
P
 = 0.024) in C-carriers. The allelic and genotypic frequencies of
APOE
polymorphism were similar between groups and did not increase the susceptibility for dyslipidemia. None of the combined
APOA5
–
APOE
polymorphisms increased risk for dyslipidemia. We demonstrated an association between
APOA5
-
1131T
>
C
polymorphism and dyslipidemia in children and adolescents. This finding may be useful to guide new studies with genetic markers down a path toward a better characterization of the genetic risk factors for dyslipidemia and atherosclerotic diseases.