Changes in Attentional Performance of Children and Young Adults With Localized Primary Brain Tumors After Conformal Radiation Therapy

• Published in: Journal of clinical oncology Vol. 24; no. 33; pp. 5283 - 5290
• Main Authors: KIEHNA, Erin N, MULHERN, Raymond K, CHENGHONG LI, XIAOPING XIONG, MERCHANT, Thomas E
• Format: Journal Article
• Language: English
• Published: Baltimore, MD American Society of Clinical Oncology 20-11-2006; Lippincott Williams & Wilkins
• Subjects: Adolescent; Adult; Attention - radiation effects; Biological and medical sciences; Brain Neoplasms - psychology; Brain Neoplasms - radiotherapy; Child; Child, Preschool; Cranial Irradiation - adverse effects; Female; Humans; Impulsive Behavior - etiology; Male; Medical sciences; Neurology; Prospective Studies; Radiotherapy, Conformal - adverse effects; Tumors; Tumors of the nervous system. Phacomatoses; Human; Performance evaluation; Nervous system diseases; Early stage; Intracranial tumor; Cerebral disorder; Conformal radiotherapy; Cancerology; Central nervous system disease; Young adult; Primary; Child; Localized
• ISSN: 0732-183X; 1527-7755
• DOI: 10.1200/JCO.2005.03.8547

To prospectively assess the impact of conformal radiation therapy (CRT) and demographic and clinical variables on four measures of attention in pediatric and young adult patients with localized primary brain tumors.
We prospectively evaluated 120 patients with primary brain tumors, ages 2 to 24.4 years (median, 9.2 years). Evaluations were done using the computerized Conners' Continuous Performance Test (CCPT). We analyzed errors of omission (inattentiveness), errors of commission (impulsivity), reaction time, and an overall index of performance before CRT, weekly during CRT, and serially up to 60 months after the start of CRT.
Before CRT, patients exhibited mild inattentiveness. During CRT, impulsivity decreased significantly (P = .002). After CRT, inattentiveness increased significantly (P = .03), and global attention disorders were associated with craniopharyngioma (P < .0001), supratentorial tumors (P = .008), optic pathway and diencephalic tumors (P = .012), and subtotal resection of the tumor (P = .010).
Brain tumors and their treatment impair sustained attention and reaction time. A decline in impulsivity and relative stability of the other CCPT scores over the course of CRT demonstrated the absence of early radiation-related cognitive sequelae. Local tumor effects, initial surgical intervention, and focal irradiation of central structures contribute to long-lasting attentional problems in pediatric and young adult patients.