Juvenile intraoral pleomorphic adenoma: report of five cases and review of the literature

• Published in: International journal of oral and maxillofacial surgery Vol. 31; no. 3; pp. 273 - 275
• Main Authors: Jorge, J., Pires, F.R., Alves, F.A., Perez, D.E.C., Kowalski, L.P., Lopes, M.A., Almeida, O.P.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01-06-2002; Elsevier
• Subjects: Adenoma, Pleomorphic - pathology; adolescence; Adolescent; Biological and medical sciences; Child; children; Dentistry; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; Humans; Immunoenzyme Techniques; Male; Medical sciences; Otorhinolaryngology. Stomatology; pleomorphic adenoma; Proliferating Cell Nuclear Antigen - analysis; Salivary Gland Neoplasms - pathology; salivary gland tumours; salivary glands; Salivary Glands, Minor - pathology; Tumor Suppressor Protein p53 - analysis; Tumors; adolescence; salivary glands; pleomorphic adenoma; children; salivary gland tumours; Human; Case study; Oral cavity; Salivary gland disease; Stomatology; Adolescent; Minor salivary gland; Pleomorphic adenoma; Bibliographic review
• ISSN: 0901-5027; 1399-0020
• DOI: 10.1054/ijom.2002.0206

The aim of this study is to report on five cases of intraoral pleomorphic adenoma (PA) in patients under 18 years of age and to review the literature. Intraoral salivary gland tumours were reviewed in two Brazilian institutions and five cases of PA in patients under 18 years of age were found. Clinical data were obtained from the medical records and paraffin-embedded tissues were sectioned for proliferating cell nuclear antigen (PCNA) and p53 immunohistochemical analysis. Four patients were female and one was male; two cases affected the palate, two the upper lip and one the tongue. All five patients were treated surgically and after long follow-up periods no recurrences were observed. Tumour cells were weakly positive for PCNA and negative for p53. PA should be considered in the differential diagnosis of submucosal nodules in young patients. In youngsters, PA seems to have similar biological characteristics as in adults, with low recurrence rates after surgical resection.