Macrocycles from simple building blocks by a multifold Heck-type coupling reaction

Macrocycles from simple building blocks by a multifold Heck-type coupling reaction

Diiodobenzenes and bisallylic alcohols—two equivalents of each—were coupled under palladium catalysis to give oxofunctionalized macrocycles as 2:2 products. The 1:1 products as medium sized rings were disfavoured and not observed. Diiodobenzenes and bisallylic alcohols lead to macrocyclic 2:2 produc...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 44; no. 43; pp. 7905 - 7907
Main Authors: Dyker, Gerald, Kadzimirsz, Daniel, Henkel, Gerald
Format: Journal Article
Language:English
Published: Elsevier Ltd 20-10-2003
Subjects:
domino processes
Heck reaction
ketones
macrocycles
palladium catalysis
Heck reaction
palladium catalysis
domino processes
ketones
macrocycles
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Summary:Diiodobenzenes and bisallylic alcohols—two equivalents of each—were coupled under palladium catalysis to give oxofunctionalized macrocycles as 2:2 products. The 1:1 products as medium sized rings were disfavoured and not observed. Diiodobenzenes and bisallylic alcohols lead to macrocyclic 2:2 products; the 1:1 products are disfavoured as medium sized rings.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2003.09.009