Animal models for the study of arterial hypertension

• Published in: Journal of biosciences Vol. 36; no. 4; pp. 731 - 737
• Main Authors: Dornas, Waleska C, Silva, Marcelo E
• Format: Journal Article
• Language: English
• Published: India Springer-Verlag 01-09-2011; Springer Nature B.V
• Subjects: Animal models; Animals; Biomedical and Life Sciences; Biomedicine; Cell Biology; Denervation - adverse effects; Diet - adverse effects; Disease Models, Animal; Etiology; Humans; Hypertension; Hypertension - etiology; Hypertension - genetics; Hypertension - physiopathology; Hypertension, Renal - etiology; Hypertension, Renal - genetics; Hypertension, Renal - physiopathology; Life Sciences; Medical research; Microbiology; Models, Animal; NG-Nitroarginine Methyl Ester - pharmacology; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - metabolism; Nitric Oxide Synthase - antagonists & inhibitors; Nitric Oxide Synthase - metabolism; Plant Sciences; Pressoreceptors - surgery; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Transgenic; Review; Zoology; cardiovascular disease; Blood pressure; experimental models; hypertension
• ISSN: 0250-5991; 0973-7138
• DOI: 10.1007/s12038-011-9097-y

Hypertension is one of the leading causes of disability or death due to stroke, heart attack and kidney failure. Because the etiology of essential hypertension is not known and may be multifactorial, the use of experimental animal models has provided valuable information regarding many aspects of the disease, which include etiology, pathophysiology, complications and treatment. The models of hypertension are various, and in this review, we provide a brief overview of the most widely used animal models, their features and their importance.