Clinical, morphologic, and biochemical characteristics of Chediak-Higashi syndrome in fifty-six Japanese black cattle

• Published in: American journal of veterinary research Vol. 58; no. 11; p. 1221
• Main Authors: Ogawa, H, Tu, C H, Kagamizono, H, Soki, K, Inoue, Y, Akatsuka, H, Nagata, S, Wada, T, Ikeya, M, Makimura, S, Uchida, K, Yamaguchi, R, Otsuka, H
• Format: Journal Article
• Language: English
• Published: United States 01-11-1997
• Subjects: Adenosine Diphosphate - pharmacology; Animals; Blood Platelets - drug effects; Blood Platelets - pathology; Blood Platelets - physiology; Cattle; Cattle Diseases - blood; Cattle Diseases - diagnosis; Cattle Diseases - physiopathology; Chediak-Higashi Syndrome - diagnosis; Chediak-Higashi Syndrome - epidemiology; Chediak-Higashi Syndrome - veterinary; Collagen - pharmacology; Cytoplasmic Granules - ultrastructure; Female; Fundus Oculi; Hemostasis; Homozygote; Japan - epidemiology; Leukocyte Count - veterinary; Male; Microscopy, Electron - methods; Microscopy, Electron - veterinary; Ophthalmoscopy - methods; Ophthalmoscopy - veterinary; Platelet Aggregation - drug effects; Platelet Count - drug effects; Platelet Count - veterinary; Japan
• ISSN: 0002-9645
• DOI: 10.2460/ajvr.1997.58.11.1221

To characterize Chediak-Higashi syndrome (C-HS) in Japanese Black cattle.
56 of 200 cattle with a bleeding disorder and giant granules in leukocytes.
Clinical observation, CBC, hemostatic screening test, platelet aggregometry, electron microscopy, platelet constituent analysis, and ophthalmoscopic examination were done.
Affected Japanese Black cattle had increased bleeding tendency and abnormal granules in their leukocytes. Susceptibility to infection was not increased. Cutaneous albinism was evident in 6 new-born calves, but not in most affected cattle. In all affected cattle, the tapetal fundus was pale and the nontapetal fundus was almost devoid of pigment. By electron microscopy, a remarkable decrease in the number of dense granules in platelets was observed. Functionally, collagen-induced platelet aggregation was markedly reduced.
This bleeding disorder was diagnosed as C-HS. With regard to susceptibility to infection, albinism, and mortality, clinical manifestations of C-HS in Japanese Black cattle were moderate, compared with C-HS in human beings and Hereford cattle.
Because an autosomal recessive mode of inheritance was documented and recessive homozygotes could be easily detected, C-HS in Japanese Black cattle can be controlled.