Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom

• Published in: Rheumatology international Vol. 31; no. 10; pp. 1355 - 1361
• Main Authors: Ghelani, Anant M., Samanta, Ash, Jones, Adrian C., Mastana, Sarabjit S.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01-10-2011; Springer Nature B.V
• Subjects: Adult; Aged; alpha-Macroglobulins - genetics; Arthritis, Rheumatoid - enzymology; Arthritis, Rheumatoid - ethnology; Arthritis, Rheumatoid - genetics; Asia - epidemiology; Asia - ethnology; Asian Continental Ancestry Group - ethnology; Asian Continental Ancestry Group - genetics; European Continental Ancestry Group - ethnology; European Continental Ancestry Group - genetics; Genetic Association Studies - methods; Glutathione Transferase - genetics; Humans; Medicine; Medicine & Public Health; Middle Aged; Original Article; Peptidyl-Dipeptidase A - genetics; Receptors, Calcitriol - genetics; Receptors, Tumor Necrosis Factor, Type II - genetics; Rheumatology; United Kingdom - epidemiology; United Kingdom - ethnology; ACE; VDR; Caucasian; TNFR2; GSTs; South Asian; A2M; RA
• ISSN: 0172-8172; 1437-160X
• DOI: 10.1007/s00296-010-1478-2

Genetic associations of TNFR2, VDR (
Bsm I
and
Fok I
), A2M, GSTT
1
, GSTM
1
and ACE in South Asian and Caucasian patients with rheumatoid arthritis (RA) were assessed in this study. DNA samples from South Asians (134 cases, 149 controls) and Caucasians (137 cases, 150 controls) from the East Midlands of the United Kingdom were genotyped for seven polymorphisms. All cases were rheumatoid-factor positive. Significant genetic associations were observed with TNFR2 R–R (OR = 3.16, CI 1.20–9.26,
P
 < 0.05), A2M 1–1 (OR = 2.09, CI 1.21–3.64,
P
 < 0.05) and GST T
1
null (OR = 1.97, CI 1.07–3.68,
P
 < 0.05) among Caucasian patients. In South Asians, VDR
Bsm I
B–B genotype (OR = 2.08, CI 1.23–3.52,
P
 < 0.05), A2M 2–2 genotype (OR = 3.99, CI 1.19–17.18,
P
 < 0.05), and GST T
1
null genotype (OR = 2.81, CI 1.40–5.77,
P
 < 0.002) genotypes were associated with RA. In the majority of cases, recessive and multiplicative modes of inheritance explained the observed associations. This study demonstrates that ethnicity affects the genetic associations in RA.