Sildenafil (Viagra) prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current

• Published in: Circulation (New York, N.Y.) Vol. 103; no. 23; p. E119
• Main Authors: Butrous, G, Siegel, R L
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 12-06-2001
• Subjects: 3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors; Administration, Oral; Animals; Biological Availability; Cation Transport Proteins; Cells, Cultured; Cricetinae; Cyclic Nucleotide Phosphodiesterases, Type 5; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System - metabolism; DNA-Binding Proteins; Dogs; Dose-Response Relationship, Drug; Electrocardiography - drug effects; Erectile Dysfunction - drug therapy; ERG1 Potassium Channel; Erythromycin - pharmacology; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Heart - drug effects; Heart Conduction System - drug effects; Humans; Male; Mixed Function Oxygenases - antagonists & inhibitors; Mixed Function Oxygenases - metabolism; Myocardium - metabolism; Piperazines - administration & dosage; Piperazines - adverse effects; Piperazines - metabolism; Piperazines - pharmacokinetics; Potassium Channel Blockers; Potassium Channels - metabolism; Potassium Channels, Voltage-Gated; Purines; Sildenafil Citrate; Sulfones; Trans-Activators; Transcriptional Regulator ERG
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/01.cir.103.23.e119