The effects of structural modifications on the insulin-releasing activity of beta-cell-tropin

The minimal effective concentration of the pituitary insulin secretagogue beta-cell-tropin (beta-CT) on the in vitro perfused pancreas was established and the effects of various modifications of the peptide on its potency were tested: iodination with 127I and acetylation reduced the insulin-releasin...

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Bibliographic Details
Published in:	Biochemical journal Vol. 244; no. 3; pp. 797 - 800
Main Authors:	Dunmore, S J, Panico, M, Etienne, A T, Morris, H R, Beloff-Chain, A
Format:	Journal Article
Language:	English
Published:	England 15-06-1987
Subjects:	Acetylation Adrenocorticotropic Hormone - pharmacology Amino Acid Sequence Animals In Vitro Techniques Insulin - metabolism Iodine Pancreas - metabolism Peptide Fragments - pharmacology Rats Structure-Activity Relationship
Online Access:	Get full text
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Summary:	The minimal effective concentration of the pituitary insulin secretagogue beta-cell-tropin (beta-CT) on the in vitro perfused pancreas was established and the effects of various modifications of the peptide on its potency were tested: iodination with 127I and acetylation reduced the insulin-releasing activity of beta-cell-tropin, and the C-terminal fragments beta-CT-(2-18), beta-CT-(3-18) and beta-CT-(6-18) were all less potent than the intact molecule; beta-CT-(1-6) was not active and did not inhibit beta-CT-induced insulin release.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0264-6021 1470-8728
DOI:	10.1042/bj2440797