Palauolol, a new anti-inflammatory sesterterpene from the sponge Fascaplysinopsis sp. from Palau

Palauolol, a new anti-inflammatory sesterterpene from the sponge Fascaplysinopsis sp. from Palau

A specimen of Fascaplysinopsis sp. from Palau contained palauolide ( 1), fascaplysin ( 2), and a new sesterterpene, palauolol ( 3). The structure and absolute stereochemistry of palauolol ( 3) were determined using spectroscopic and chemical methods and in doing so, the absolute stereochemistry of p...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 37; no. 23; pp. 3951 - 3954
Main Authors: Schmidt, Eric W., John Faulkner, D.
Format: Journal Article
Language:English
Published: Elsevier Ltd 03-06-1996
Online Access:Get full text
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Summary:A specimen of Fascaplysinopsis sp. from Palau contained palauolide ( 1), fascaplysin ( 2), and a new sesterterpene, palauolol ( 3). The structure and absolute stereochemistry of palauolol ( 3) were determined using spectroscopic and chemical methods and in doing so, the absolute stereochemistry of palauolide was also determined. Palauolide ( 1) and palauolol ( 3) both inactivate bee venom phospholipase A 2. The structure and absolute configuration of palauolol, a new anti-inflammatory sesterterpene from Fascaplysinopsis sp., were determined by spectroscopic methods.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(96)00718-6