Akkermansia muciniphila : a deworming partner independent of type 2 immunity

• Published in: Gut microbes Vol. 16; no. 1; p. 2338947
• Main Authors: Wang, Jiaqi, Zhao, Xiufeng, Li, Xianhe, Jin, Xuemin
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis Group 2024
• Subjects: Akkermansia; Akkermansia muciniphila; Animals; Gastrointestinal Microbiome; gut microbiota; helminth; Helminthiasis - immunology; Helminths - genetics; Helminths - immunology; Humans; immunity; Trichinella spiralis; Verrucomicrobia - genetics; Verrucomicrobia - immunology; Trichinella spiralis; Akkermansia muciniphila; helminth; immunity; gut microbiota
• ISSN: 1949-0976; 1949-0984; 1949-0984
• DOI: 10.1080/19490976.2024.2338947

The gut microbiota has coevolved with the host for hundreds of millions of years, playing a beneficial role in host health. Human parasitic helminths are widespread and pose a pervasive global public health issue. Although Type 2 immunity provides partial resistance to helminth infections, the composition of the gut microbiota can change correspondingly. Therefore, it raises the question of what role the gut microbiota plays during helminth infection.
has emerged as a notable representative of beneficial microorganisms in the gut microbiota. Recent studies indicate that
is not merely associated with helminth infection but is also causally linked to infection. Here, we provide an overview of the crosstalk between
and enteric helminth infection. Our goal is to enhance our understanding of the interplay among
, helminths, and their hosts while also exploring the potential underlying mechanisms.