Serum hyaluronan (hyaluronic acid) in breast cancer patients

Eighty-three women with breast cancer (57 with systemic metastasis, 26 without) were investigated for serum hyaluronan (HA) and compared to 50 patients with benign diseases of the breast. Hyaluronan was significantly increased in sera of metastatic patients compared to sera of non-metastatic patient...

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Bibliographic Details
Published in:	International journal of cancer Vol. 46; no. 3; p. 388
Main Authors:	Delpech, B, Chevallier, B, Reinhardt, N, Julien, J P, Duval, C, Maingonnat, C, Bastit, P, Asselain, B
Format:	Journal Article
Language:	English
Published:	United States 15-09-1990
Subjects:	Biomarkers, Tumor - blood Breast Neoplasms - blood Breast Neoplasms - pathology Breast Neoplasms - therapy Female Fibrocystic Breast Disease - blood Humans Hyaluronic Acid - blood Neoplasm Metastasis
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Summary:	Eighty-three women with breast cancer (57 with systemic metastasis, 26 without) were investigated for serum hyaluronan (HA) and compared to 50 patients with benign diseases of the breast. Hyaluronan was significantly increased in sera of metastatic patients compared to sera of non-metastatic patients (p less than 0.0001) and also in sera of non-metastatic patients when compared to control sera (p less than 0.01). The difference was not related to the number of metastatic sites involved. Three months after starting cytotoxic chemotherapy in metastatic patients, lower HA concentrations were observed in patients responding to chemotherapy. The initial level of serum HA had no predictive value concerning response to chemotherapy.
ISSN:	0020-7136
DOI:	10.1002/ijc.2910460309