Synthesis and antimicrobial activity of new 4-thiazolidinone derivatives containing 2-amino-6-methoxybenzothiazole

• Published in: Saudi pharmaceutical journal Vol. 18; no. 3; pp. 129 - 136
• Main Authors: Patel, Navin B., Shaikh, Faiyazalam M.
• Format: Journal Article
• Language: English
• Published: Saudi Arabia Elsevier B.V 01-07-2010
• Subjects: 2-Amino-6-methoxybenzothiazole; 2-Chloro pyridine-3-carboxylic acid; 4-Thiazolidinones; Antimicrobial activity; Original; Schiff bases; 2-Chloro pyridine-3-carboxylic acid; Schiff bases; Antimicrobial activity; 2-Amino-6-methoxybenzothiazole; 4-Thiazolidinones
• ISSN: 1319-0164; 2213-7475
• DOI: 10.1016/j.jsps.2010.05.002

A novel series of Schiff bases
5a–
j and 4-thiazolidinones
6a–
j have been prepared from the building blocks 2-chloro pyridine-3-carboxylic acid [
1] and 2-amino-6-methoxy-benzothiazole [
2]. All of the synthesized compounds have been confirmed by elemental analyses, IR,
1H NMR and
13C NMR spectral data. These newly synthesized compounds were screened for their antimicrobial activity. Variable and modest activity was observed against the investigated strains of bacteria and fungi, however, compound
6h revealed significant antibacterial activity against
Escherichia coli. Compounds
1,
2,
3,
5c,
5g and
5h, on the other hand, revealed potent antifungal activity against
Candida albicans compared to the reference drug greseofulvin.