Synthesis, characterization, biological and catalytic applications of transition metal complexes derived from Schiff base

• Published in: Bioorganic & medicinal chemistry letters Vol. 24; no. 15; pp. 3559 - 3564
• Main Authors: Bushra Begum, A, Rekha, N D, Vasantha Kumar, B C, Lakshmi Ranganatha, V, Khanum, Shaukath Ara
• Format: Journal Article
• Language: English
• Published: England 01-08-2014
• Subjects: Angiogenesis Inhibitors - chemical synthesis; Angiogenesis Inhibitors - chemistry; Angiogenesis Inhibitors - pharmacology; Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Catalysis; Cattle; Cell Proliferation - drug effects; DNA - chemistry; DNA - drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fluorescence; Molecular Structure; Neoplasms - drug therapy; Neoplasms - pathology; Neovascularization, Pathologic - drug therapy; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Schiff Bases - chemistry; Structure-Activity Relationship; Transition Elements - chemistry; Schiff base ligand; Angiogenesis; Binding/cleavage of DNA
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2014.05.046

A novel series of Cu(II), Ni(II), Zn(II), Co(II), and Cd(II) complexes have been synthesized from the Schiff base. Structural features were determined by analytical and spectral techniques like IR, (1)H NMR, UV-vis, elemental analysis, molar electric conductibility, magnetic susceptibility and thermal studies. The complexes are found to be soluble in dimethylformamide and dimethylsulfoxide. Molar conductance values in dimethylformamide indicate the non-electrolytic nature of the complexes. Binding of synthesized complexes with calf thymus DNA (CT DNA) was studied. There is significant binding of DNA in lanes 2, 3, and 5. Lanes 4 and 6 are showing more florescence when compared to the control indicating that these molecules are strongly bound to the DNA by inserting themselves between the two stacked base pairs and exhibiting their original property of fluorescence. Angiogenesis study has revealed that the compounds B-2, B-4 and B-5 have potent antitumor efficacy and activation of antiangiogenesis could be one of the possible underlying mechanisms of tumor inhibition.