Age-related changes in antioxidant status and oxidative damage to lipids and dna in mitochondria of rat liver

Age-related changes in antioxidant status and oxidative damage to lipids and dna in mitochondria of rat liver

To investigate the correlation between oxidative stress and mitochondrial damage with aging, antioxidant system, levels of oxidative DNA damage and as an index of the loss of plasma membrane integrity lipid peroxidation and membrane potential were studied. Results showed that the activities of antio...

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Bibliographic Details
Published in:Process biochemistry (1991) Vol. 40; no. 2; pp. 903 - 908
Main Authors: Valls, V., Peiro, C., Muñiz, P., Saez, G.T.
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-02-2005
Subjects:
Antioxidant enzymes
DNA damage
GSH
Lipid peroxidation
Membrane potential
Lipid peroxidation
Membrane potential
GSH
Antioxidant enzymes
DNA damage
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Summary:To investigate the correlation between oxidative stress and mitochondrial damage with aging, antioxidant system, levels of oxidative DNA damage and as an index of the loss of plasma membrane integrity lipid peroxidation and membrane potential were studied. Results showed that the activities of antioxidant enzymes superoxide dismutase (SOD) and catalase significantly decreased during aging, however glutathione peroxidase (GSH-PX) increased in the aged mitochondria and glutathione (GSH) did not change during aging. No statistical difference was observed in the lipid peroxidation of mitochondria between young and old animals. The level of oxidative DNA damage (measured as 8oxo-dG) tended to increase during aging.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1359-5113
1873-3298
DOI:10.1016/j.procbio.2004.02.025