Thymosin beta 4: a ubiquitous peptide in rat and mouse tissues

Thymosin beta 4: a ubiquitous peptide in rat and mouse tissues

Thymosin beta 4, recently isolated from calf thymus, is present in a number of rat and mouse tissues, including spleen, thymus, brain, lung, liver, and heart muscle. High concentrations are found in peritoneal macrophages, suggesting that its occurrence in other tissues may be related to the presenc...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS Vol. 79; no. 7; pp. 2172 - 2175
Main Authors: Hannappel, E, Xu, G J, Morgan, J, Hempstead, J, Horecker, B L
Format: Journal Article
Language:English
Published: United States National Acad Sciences 01-04-1982
Subjects:
Animals
Ascitic Fluid - cytology
Brain - metabolism
Chromatography, High Pressure Liquid
Macrophages - metabolism
Mice
Mice, Nude - metabolism
Rats
Species Specificity
Spleen - metabolism
Thymosin - analogs & derivatives
Thymosin - metabolism
Thymus Gland - metabolism
Thymus Hormones - metabolism
Tissue Distribution
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Summary:Thymosin beta 4, recently isolated from calf thymus, is present in a number of rat and mouse tissues, including spleen, thymus, brain, lung, liver, and heart muscle. High concentrations are found in peritoneal macrophages, suggesting that its occurrence in other tissues may be related to the presence of macrophages or macrophage-like cells in these tissues. The conclusion that "thymosin" beta 4 does not originate solely in the thymus gland is supported by the high concentrations found in tissues of athymic (nu/nu) mice.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.79.7.2172