Anti- Helicobacter pylori activity and inhibition of gastritis by Allium hookeri extract

• Published in: Laboratory animal research Vol. 34; no. 2; pp. 75 - 79
• Main Authors: Lee, Hyun-A, Hong, Sunhwa, Yoo, Ji-Hyun, Chung, Yungho, Kim, Okjin
• Format: Journal Article
• Language: English
• Published: England Korean Association for Laboratory Animal Science 01-06-2018; BMC; 한국실험동물학회
• Subjects: Allium hookeri; gastritis; H. pylori; Helicobacter; inhibition; Original; 수의학; inhibition; H. pylori; Helicobacter; gastritis; Allium hookeri
• ISSN: 1738-6055; 2233-7660
• DOI: 10.5625/lar.2018.34.2.75

is widely consumed plant as a vegetable and herbal medicine in southeastern Asia.
has been reported antioxidant, improvement of bone health and antidiabetic effects. In the present study, we investigated the potential inhibitory effect of
extract (AHE) on
. The
anti-bacterial activities of AHE were determined by disk agar diffusion method. Also, the inhibition effect of the AHE on
infection was investigated using a mouse model.
colonization was confirmed by rapid urease tests, as described previously. Mucosal damage was evaluated grossly and histologically according to previously described criteria. As the results of the disk agar diffusion assay, CLR, AMX and MTZ inhibited the bacterial growth with inhibition zone of 19.2, 15.2 and 7.5 mm, respectively. AHE 100 µg/mL showed an inhibition zone value of 20.6 mm. Rapid urease tests of the mice stomachs demonstrated a significant reduction in
colonization. In addition to the therapeutic effect against
infection, the AHE reduced mucosal inflammation and epithelial damages in the stomach of
-infected mice. These results demonstrate that the AHE successfully cured an
infection and treated the
infection. This AHE could be a promising treatment for patients with gastric complaints including gastritis caused by
.