Substance P: Does it Produce Analgesia or Hyperalgesia?

In the hot plate test, substance P given intravenously at doses of 5 $\times $ 10$^{-5}$ and 5 $\times $ 10$^{-4}$ gram per kilogram caused analgesia, while lower doses caused hyperalgesia. The influence of substance P on nociception depended on the individual mouse's sensitivity to pain (contr...

Full description

Saved in:

Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 208; no. 4441; pp. 305 - 307
Main Authors:	Oehme, Peter, Hilse, Heinz, Morgenstern, Eveline, Gores, Erhard
Format:	Journal Article
Language:	English
Published:	United States The American Association for the Advancement of Science 18-04-1980
Subjects:	Acetates Analgesia Analgesics Animals Dosage Dose-Response Relationship, Drug Hot Temperature Hyperalgesia Hyperalgesia - chemically induced Hyperesthesia - chemically induced Intravenous injections Mice Molecules Nociceptors - drug effects Pain Pain - physiopathology Perception - drug effects Receptors, Drug - physiology Substance P - pharmacology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	In the hot plate test, substance P given intravenously at doses of 5 $\times $ 10$^{-5}$ and 5 $\times $ 10$^{-4}$ gram per kilogram caused analgesia, while lower doses caused hyperalgesia. The influence of substance P on nociception depended on the individual mouse's sensitivity to pain (control response latency). Analgesia was produced by substance P administered to mice with high sensitivity to thermic stimulation, whereas hyperalgesia occurred in mice whose control latencies were longer than normal. This result is interpreted as an indication that substance P is capable of normalizing responsiveness to pain and could be classified as a regulatory peptide.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.6154313