Is the antibody response specific?

Introduction of heterologous immunoglobulin (Ig) or red blood cells into mice results in an increased production of Ig and immunogen-reactive antibody. Since the increase in both total Ig and specific antibody is similar, it is concluded that the antibody response is specific. This result, which con...

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Bibliographic Details
Published in:	European journal of immunology Vol. 16; no. 5; p. 557
Main Author:	Etlinger, H M
Format:	Journal Article
Language:	English
Published:	Germany 01-05-1986
Subjects:	Age Factors Animals Antibodies - classification Antibody Formation Antibody Specificity B-Lymphocytes - immunology Cell Differentiation Dose-Response Relationship, Immunologic Erythrocytes - immunology gamma-Globulins - immunology Immunoglobulin G - immunology Lymphocyte Activation Mice
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Summary:	Introduction of heterologous immunoglobulin (Ig) or red blood cells into mice results in an increased production of Ig and immunogen-reactive antibody. Since the increase in both total Ig and specific antibody is similar, it is concluded that the antibody response is specific. This result, which contrasts with those of previous studies in which the production of large amounts of nonspecific Ig was reported, suggests that in vivo T-dependent B cell activation and differentiation to plasma cells requires the presence of immunogen and linked recognition.
ISSN:	0014-2980
DOI:	10.1002/eji.1830160517