Diminished adherence of sickle erythrocytes to cultured vascular endothelium by piracetam

Erythrocytes from both normal and sickle cell donors were incubated on a bed of cultured rat vascular endothelial cells. Although the adherence of the erythrocytes to the endothelial cells was equivalent for both classes of donor, addition of 1.5 mM piracetam significantly decreased this adherence r...

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Bibliographic Details
Published in:	American journal of hematology Vol. 15; no. 2; p. 147
Main Authors:	Nalbandian, R M, Henry, R L, Burek, C L, Diglio, C A, Goldman, A I, Taylor, G W, Hoffman, W H
Format:	Journal Article
Language:	English
Published:	United States 01-09-1983
Subjects:	Anemia, Sickle Cell - blood Animals Cell Adhesion - drug effects Cells, Cultured Endothelium - physiology Erythrocytes, Abnormal - drug effects Humans Piracetam - pharmacology Pyrrolidinones - pharmacology Rats
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Summary:	Erythrocytes from both normal and sickle cell donors were incubated on a bed of cultured rat vascular endothelial cells. Although the adherence of the erythrocytes to the endothelial cells was equivalent for both classes of donor, addition of 1.5 mM piracetam significantly decreased this adherence regardless of donor.
ISSN:	0361-8609
DOI:	10.1002/ajh.2830150206