Appendectomy is more frequent but not a risk factor in Crohn's disease while being protective in ulcerative colitis: a comparison of surgical procedures in inflammatory bowel disease

• Published in: The American journal of gastroenterology Vol. 96; no. 3; pp. 829 - 832
• Main Authors: Reif, Shimon, Lavy, Alexandra, Keter, Daniel, Broide, Efrat, Niv, Yaron, Halak, Aharon, Ron, Yishai, Eliakim, Rami, Odes, Shmuel, Patz, Julian, Fich, Alexander, Villa, Yael, Arber, Nadir, Gilat, Tuvia
• Format: Journal Article
• Language: English
• Published: Oxford . 01-03-2001; Blackwell Publishing; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Adult; Appendectomy - statistics & numerical data; Biological and medical sciences; Cholecystectomy - statistics & numerical data; Colitis, Ulcerative - prevention & control; Crohn Disease - etiology; Female; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Inflammatory bowel disease; Male; Medical sciences; Middle Aged; Other diseases. Semiology; Reference Values; Risk Factors; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tonsillectomy - statistics & numerical data; Tropical medicine; Asia; Israel; Human; Crohn disease; Appendectomy; Vermiform appendix; Surgery; Digestive diseases; Intestinal disease; Biological effect; Epidemiology; Inflammatory disease; Incidence; Ulcerative colitis
• ISSN: 0002-9270; 1572-0241
• DOI: 10.1111/j.1572-0241.2001.03529.x

Appendectomy was shown to be protective in patients with ulcerative colitis (UC). There are fewer data in Crohn's disease (CD). Other operations were less studied. The aim of this study was to investigate the prevalence of appendectomy, cholecystectomy, and tonsillectomy, including their timing, in patients with inflammatory bowel disease in comparison to controls. Two hundred seventy-one patients with UC and 260 with CD, 475 clinic controls, and 428 community controls were interviewed. Appendectomy was found in 5.5% patients with UC, in 11% of clinic controls (p < 0.05), and 7.7% of community controls (p = not significant). The differences were more significant for appendectomy before onset of disease. Appendectomy was performed in 19.2% of patients with CD, in 10.9% of clinic controls, and in 10.1% of community controls (p < 0.01). However, there were no significant differences when only appendectomy before onset of disease was considered. Cholecystectomy was found in 1.5% of patients with UC, in 6.1% of clinic controls (p < 0.01), and in 4.5% of community controls (p = not significant). The difference remained significant when confined to operations performed before disease onset. No such difference was found in patients with CD. No significant difference was found in the prevalence of tonsillectomy between patients and controls. Appendectomy is protective in UC; it is more frequent, but not a risk factor in CD. The role of cholecystectomy should be investigated further.