Fabrication and properties of multi-functional polydopamine coated Cu/F-codoped hydroxyapatite hollow microspheres as drug carriers

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 222; p. 113097
• Main Authors: Jiang, Xiaodan, Liu, Xiaowei, Cai, Jiayi, Wei, Shibo, Wang, Yanan, Duan, Zhuqing, Zhou, Zeao, Sun, Ruixue, Qu, Xiaofei, Tang, Yuanzheng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-02-2023
• Subjects: Doxorubicin - chemistry; Drug Carriers - chemistry; Drug delivery; Drug Liberation; Durapatite - chemistry; Dynamic simulation; Hydroxyapatite; Ion-doping; Microspheres; Polydopamine; Polymers - chemistry; Polydopamine; Dynamic simulation; Hydroxyapatite; Drug delivery; Ion-doping
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2022.113097

Due to its excellent bone conductivity and drug adsorption as well as pH-responsive drug release property, hydroxyapatite (HAp) is widely used as a drug carrier in bone repair field. Here, we report for the first time a novel multi-functional polydopamine (PDA) coated Cu/F-codoped HAp (Cu/F-HAp-PDA) hollow microspheres. Both Cu2+ and F- were successfully doped into the lattice of HAp and uniformly distributed in the shell of hollow microspheres through a one-step hydrothermal synthesis. Then PDA was coated homogeneously on the outer layer of Cu/F-HAp hollow microspheres. Both Cu/F-HAp and Cu/F-HAp-PDA samples displayed high drug loading efficiency and pH responsive drug release behavior. Moreover, the obtained Cu/F-HAp-PDA hollow microspheres exhibited excellent photothermal conversion efficiency and photothermal stability. The molecular dynamics simulations showed that PDA and HAp can form mutual binding mainly through Ca-O bonding, while doxorubicin (DOX) is mainly bound to PDA molecules through hydrogen bonding and π-π stacking interaction.
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•PDA coated Cu/F-codoped HAp hollow microspheres were successfully fabricated.•PDA coated Cu/F-HAp exhibits excellent photothermal conversion efficiency.•PDA coated Cu/F-HAp show high DOX loading efficiency and sustained release.•The binding between PDA and HAp is mainly realized through Ca-O and O-H bonds.•DOX and PDA could interact with each other through hydrogen bond and π-π stacking.