Intracerebroventricular injections of endotoxin (ET) reduces hippocampal neurogenesis

• Published in: Journal of neuroimmunology Vol. 315; pp. 58 - 67
• Main Authors: Chamaa, Farah, Bitar, Lynn, Darwish, Batoul, Saade, Nayef E., Abou-Kheir, Wassim
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15-02-2018
• Subjects: Dentate gyrus; Endotoxin; Neurodegeneration; Neurogenesis; Neuroinflammation; NSAID; NPC; PSC; DG; NSAID; ip; SGZ; Neuroinflammation; Endotoxin; Neurogenesis; ET; GCL; Dentate gyrus; Neurodegeneration; SVZ; MG; icv
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/j.jneuroim.2017.12.013

Physio-pathological conditions such as neuroinflammation can modulate neurogenesis in the hippocampus. The aim of this study is to follow the time course of inflammation-induced effects on the neurogenic niche and the counter-effects of an anti-inflammatory drug. Rats received intracerebroventricular injections of lipopolysaccharide/endotoxin (ET) and intraperitoneal injections of 5′-bromo-2′-deoxyuridine, then perfused at different time intervals. At day 3, ET injection resulted in thermal hyperalgesia accompanied by a significant decrease in neurogenesis. A rebound of neurogenesis was detected at day 6 and levels were back to basal at day 9. Daily treatment with Piroxicam alleviated the ET-induced effects.
[Display omitted]
•ICV-injection of ET decreases adult hippocampal neurogenesis.•Moderate inflammation was induced by endotoxin injection in the brain.•This resulted into a decrease of hippocampal neurogenesis.•Endotoxin injection induced thermal hyperalgesia that peaked at day 3.•Both effects were reversed when inflammation was resolved.