Nanoemulsion delivery systems for oil-soluble vitamins: Influence of carrier oil type on lipid digestion and vitamin D3 bioaccessibility

• Published in: Food chemistry Vol. 187; pp. 499 - 506
• Main Authors: Ozturk, Bengu, Argin, Sanem, Ozilgen, Mustafa, McClements, David Julian
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15-11-2015
• Subjects: Bioaccessibility; Bioavailability; Biological Availability; Calcifediol; Calcitriol; Carrier oil; Cholecalciferol; Cholecalciferol - chemistry; Cholecalciferol - metabolism; Digestion; Drug Carriers - chemistry; Drug Delivery Systems - instrumentation; Drug Delivery Systems - methods; Emulsions - chemistry; Emulsions - metabolism; Gastrointestinal Tract - metabolism; Humans; Models, Biological; Nanoemulsions; Oils - chemistry; Quillaja saponin; Surface-Active Agents - chemistry; Vitamin D3; Vitamin D3; Cholecalciferol; Carrier oil; Calcitriol; Nanoemulsions; Calcifediol; Bioaccessibility; Digestion; Bioavailability; Quillaja saponin; Vitamin D
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2015.04.065

•Vitamin-enriched nanoemulsions were prepared using a natural surfactant.•Lipid digestion and vitamin D3 bioaccessibility strongly depend on carrier oil type.•Medium chain triglycerides were rapidly digested, but gave low bioavailability.•Long chain triglycerides were most effective at increasing vitamin bioaccessibility.
The influence of carrier oil type on the bioaccessibility of vitamin D3 encapsulated within oil-in-water nanoemulsions prepared using a natural surfactant (quillaja saponin) was studied using a simulated gastrointestinal tract (GIT) model: mouth; stomach; small intestine. The rate of free fatty acid release during lipid digestion decreased in the following order: medium chain triglycerides (MCT)>corn oil≈fish oil>orange oil>mineral oil. Conversely, the measured bioaccessibility of vitamin D3 decreased in the following order: corn oil≈fish oil>orange oil>mineral oil>MCT. These results show that carrier oil type has a considerable impact on lipid digestion and vitamin bioaccessibility, which was attributed to differences in the release of bioactives from lipid droplets, and their solubilization in mixed micelles. Nanoemulsions prepared using long chain triglycerides (corn or fish oil) were most effective at increasing vitamin bioaccessibility.