Successful switch to cisplatin-based chemotherapy in a patient with lung cancer who developed a carboplatin-induced hypersensitivity reaction

• Published in: Journal of oncology pharmacy practice Vol. 30; no. 4; pp. 772 - 776
• Main Authors: Nagata, Yuko, Toyokawa, Gouji, Sugiyama, Akiko, Shimamatsu, Shinichiro, Saitoh, Ohki, Okubo, Hiroshi, Ueda, Hitoshi
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-06-2024; Sage Publications Ltd
• Subjects: Aged; Anaphylaxis; Antibodies, Monoclonal, Humanized - adverse effects; Antibodies, Monoclonal, Humanized - therapeutic use; Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Apoptosis; Blood pressure; Carboplatin; Carboplatin - administration & dosage; Carboplatin - adverse effects; Carboplatin - therapeutic use; Carcinoma, Non-Small-Cell Lung - drug therapy; Chemotherapy; Cisplatin; Cisplatin - administration & dosage; Cisplatin - adverse effects; Cisplatin - therapeutic use; Drug Hypersensitivity; Drug Substitution; Humans; Hypersensitivity; Hypotension; Leukocytes (basophilic); Lung cancer; Lung Neoplasms - drug therapy; Male; Non-small cell lung carcinoma; Paclitaxel; Paclitaxel - administration & dosage; Paclitaxel - adverse effects; Paclitaxel - therapeutic use; Pembrolizumab; Platinum; Small cell lung carcinoma; hypersensitivity reaction; carboplatin; platinum-doublet; Non-small cell lung cancer
• ISSN: 1078-1552; 1477-092X; 1477-092X
• DOI: 10.1177/10781552241234847

Introduction
Platinum-based chemotherapy is the mainstay of first-line therapy for advanced-stage non-small cell lung cancer (NSCLC). Although carboplatin-induced hypersensitivity reactions (HSRs) commonly occur following multiple cycles of therapy, they are rarely observed during the first cycle of the treatment.
Case report
Here, we report the case of a 70-year-old man with advanced-stage NSCLC who developed HSR possibly caused by carboplatin during the first cycle of induction with platinum-doublet chemotherapy plus pembrolizumab. The patient presented with bronchial obstruction due to a centrally located tumor. No driver mutations were detected, and the programmed death-ligand 1 expression ranged from 1% to 24%. Consequently, the patient was treated with pembrolizumab combined with carboplatin and paclitaxel. However, immediately after the start of carboplatin, the blood pressure and oxygen levels of the patient dropped and he began exhibiting an altered level of consciousness. These findings indicated carboplatin-induced anaphylaxis. Hypotension and oxygen desaturation improved following carboplatin discontinuation and normal saline administration.
Management and outcome
The basophil activation test for both carboplatin and cisplatin was negative. Thus, the risk of anaphylaxis owing to both drugs was ruled out, and carboplatin was believed to have induced grade 3 HSR. Subsequently, carboplatin-based chemotherapy was switched to cisplatin-based chemotherapy. HSR was not observed during the four treatment cycles with pembrolizumab, cisplatin, and pemetrexed, and best response was partial response.
Discussion
Cisplatin-based chemotherapy could be used as an alternate treatment in patients with NSCLC who develop severe carboplatin-induced HSR.