Buckwheat-enriched diet alleviates bisphenol A mediated oxidative stress via modulation of sirtuin 1 and antioxidant status in experimental rats

• Published in: Food chemistry Vol. 373; no. Pt B; p. 131507
• Main Authors: Pande, Shubhra, Ranjan, Rajeev, Ryazanova, Maria, Shuvaev, Anton N., Salmina, Alla B., Kratasyuk, Valentina A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 30-03-2022
• Subjects: Animals; Antioxidants - metabolism; Benzhydryl Compounds - metabolism; Bisphenol A; Buckwheat; Catalase - metabolism; Diet; Dietary intervention; Fagopyrum - metabolism; Liver - metabolism; Male Wistar rats; Oxidative Stress; Phenols; Rats; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Sirtuin1; Bisphenol A; Oxidative stress; Dietary intervention; Male Wistar rats; Sirtuin1; Buckwheat
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2021.131507

•Dietary buckwheat countered bisphenol-A (BPA) induced oxidative stress in rats.•Buckwheat enhanced sirtuin1 levels without affecting body weight.•BPA did not affect sirtuin1 levels at given dose (10 mg L−1).
Present study investigated effect of dietary buckwheat in alleviating bisphenol A (BPA) mediated oxidative stress, concomitant sirtuin1 levels in serum, stomach, and liver of rats. Experimental group A and B ingested standard diet, C and D consumed buckwheat (30%); group A and C drank normal water, B and C had BPA contamination (10 mg L−1). Sirtuin1 mean B/A ratio nearing unity in all tissues reveals inertness of BPA towards sirtuin1. Dietary buckwheat improved sirtuin1 levels both in normal (mean C/A ratio of serum, 1.65; liver, 1.24; stomach, 1.78) and BPA fed state (mean D/B ratio of serum, 1.9; liver, 1.26; stomach, 1.75). Buckwheat augmented antioxidant status in BPA fed rats as seen in mean D/B ratio of serum (catalase, 2.4; glutathione reductase (GR), 1.33; Thiols, 1.2), liver (catalase, 2; GR, 2.5; Thiols, 1.36) and stomach (catalase, 1.31; GR, 1.5; Thiols, 1.33). Therefore, buckwheat counters BPA-led oxidative stress and modulates sirtuin1.