Improving free-viewing fixation-related EEG potentials with continuous-time regression

• Published in: Journal of neuroscience methods Vol. 313; pp. 77 - 94
• Main Authors: Cornelissen, Tim, Sassenhagen, Jona, Võ, Melissa Le-Hoa
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-02-2019
• Subjects: EEG; Eye movements; Eye tracking; Free viewing; FRP; Regression; rFRP; FRP; Free viewing; EEG; rFRP; Regression; Eye movements; Eye tracking
• ISSN: 0165-0270; 1872-678X
• DOI: 10.1016/j.jneumeth.2018.12.010

•Averaging methods for estimating eye fixation-locked ERPs suffer from confounds.•Multiple regression can be used to control response overlap and covariates.•Regression is favorable to averaging in free-viewing Eye Tracking-EEG data.
In the analysis of combined ET-EEG data, there are several issues with estimating FRPs by averaging. Neural responses associated with fixations will likely overlap with one another in the EEG recording and neural responses change as a function of eye movement characteristics. Especially in tasks that do not constrain eye movements in any way, these issues can become confounds.
Here, we propose the use of regression based estimates as an alternative to averaging. Multiple regression can disentangle different influences on the EEG and correct for overlap. It thereby accounts for potential confounds in a way that averaging cannot. Specifically, we test the applicability of the rERP framework, as proposed by Smith and Kutas (2015b), (2017), or Sassenhagen (2018) to combined eye tracking and EEG data from a visual search and a scene memorization task.
Results show that the method successfully estimates eye movement related confounds in real experimental data, so that these potential confounds can be accounted for when estimating experimental effects.
The rERP method successfully corrects for overlapping neural responses in instances where averaging does not. As a consequence, baselining can be applied without risking distortions. By estimating a known experimental effect, we show that rERPs provide an estimate with less variance and more accuracy than averaged FRPs. The method therefore provides a practically feasible and favorable alternative to averaging.
We conclude that regression based ERPs provide novel opportunities for estimating fixation related EEG in free-viewing experiments.