Isoniazid-associated psychosis: case report and review of the literature

• Published in: The Annals of pharmacotherapy Vol. 27; no. 2; p. 167
• Main Authors: Pallone, K A, Goldman, M P, Fuller, M A
• Format: Journal Article
• Language: English
• Published: United States 01-02-1993
• Subjects: Aged; Humans; Incidence; Isoniazid - adverse effects; Male; Psychoses, Substance-Induced - etiology
• ISSN: 1060-0280
• DOI: 10.1177/106002809302700205

To describe a case of isoniazid-associated psychosis and review the incidence of this adverse effect.
Information about the patient was obtained from the medical chart. A MEDLINE search of the English-language literature published from 1950 to 1992 was conducted and Index Medicus was manually searched for current information.
All case reports describing isoniazid-associated psychosis were reviewed.
Studies were evaluated for the use of isoniazid, symptoms of psychosis, onset of symptoms, and dosage of isoniazid.
The case report is compared with others reported in the literature. The incidence of isoniazid-associated psychosis is rare.
The mechanism of isoniazid-associated psychosis is uncertain. It appears that isoniazid was associated with the psychosis evident in our patient and in the cases reviewed.