Magnetic nanocellulose alginate hydrogel beads as potential drug delivery system

• Published in: International journal of biological macromolecules Vol. 118; no. Pt A; pp. 640 - 648
• Main Authors: Supramaniam, Jagadeesen, Adnan, Rohana, Mohd Kaus, Noor Haida, Bushra, Rani
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15-10-2018
• Subjects: Alginate hydrogel beads; Drug delivery; Ibuprofen; Magnetic cellulose nanocrystals; Rice husks; Rice husks; Drug delivery; Alginate hydrogel beads; Magnetic cellulose nanocrystals; Ibuprofen
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2018.06.043

Magnetic nanocellulose alginate hydrogel beads are produced from the assembly of alginate and magnetic nanocellulose (m-CNCs) as a potential drug delivery system. The m-CNCs were synthesized from cellulose nanocrystals (CNCs) that were isolated from rice husks (RH) by co-precipitation method and were incorporated into alginate-based hydrogel beads with the aim of enhancing mechanical strength and regulating drug release behavior. Ibuprofen was chosen as a model drug. The prepared CNCs, m-CNCs and the alginate hydrogel beads were characterized by various physicochemical techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM) and vibrating sample magnetometer studies (VSM). Besides the magnetic property, the presence of m-CNCs increased the integrity of the alginate hydrogel beads and the swelling percentage. The drug release study exhibited a controlled release profiles and based on the drug release data, the drug release mechanism was analyzed and discussed based on mathematical models such as Korsmeyer-Peppas and Peppas-Sahlin.