Cronkhite–Canada syndrome tends to be accompanied by colorectal cancer: Report of seven cases

• Published in: JGH open Vol. 8; no. 10; pp. e70032 - n/a
• Main Authors: Shimoyama, Masayuki, Iwagami, Hiroyoshi, Minaga, Kosuke, Akamatsu, Takuji, Uenoyama, Yoshito, Yamashita, Yukitaka
• Format: Journal Article
• Language: English
• Published: Melbourne Wiley Publishing Asia Pty Ltd 01-10-2024; John Wiley & Sons, Inc; Wiley
• Subjects: Alopecia; Baldness; Case Report; Colonoscopy; Colorectal cancer; Cronkhite–Canada syndrome; Diarrhea; endoscopes; Endoscopy; Gastrointestinal cancer; Hospitals; Inflammation; Medical prognosis; mucosal inflammation; Patients; polyposis; Polyps; Rectum; Remission (Medicine); Stomach; Surveillance; Taste disorders; Canada; colorectal cancer; mucosal inflammation; endoscopes; Cronkhite–Canada syndrome; polyposis
• ISSN: 2397-9070; 2397-9070
• DOI: 10.1002/jgh3.70032

Cronkhite–Canada syndrome (CCS) can be difficult to diagnose. To diagnose CCS, it is important to perform endoscopic examination for patients with chronic diarrhea, check for the presence or absence of polyposis, and evaluate inflammation in the mucosa between the polyps. This study reported seven cases of CCS. The age of the patients, which included four men and three women, ranged 48–72 years, and all patients were Asian. The most common symptom among these patients was chronic diarrhea. Three of the patients had rectal cancer. In two patients, the lesions were detected at an early stage and resected via endoscopic treatment. CCS is associated with a high risk of malignant gastrointestinal lesions, especially rectal cancers, and periodic surveillance endoscopy and careful observation are required.
To accurately diagnose CCS (Cronkhite–Canada syndrome), it is important to recommend endoscopic examination for patients with chronic diarrhea and confirm the presence or absence of polyposis and inflammation in the mucosa between the polyps. Moreover, CCS is associated with a high risk of gastrointestinal malignant lesions, especially rectal cancer, and periodic surveillance endoscopy and careful observation are required.