Relationship of Neutrophil-to-Lymphocyte Ratio and Serum Albumin Levels with C-Reactive Protein in Hemodialysis Patients: Results from 2 International Cohort Studies

• Published in: Nephron (2015) Vol. 130; no. 4; p. 263
• Main Authors: Malhotra, Rakesh, Marcelli, Daniele, von Gersdorff, Gero, Grassmann, Aileen, Schaller, Mathias, Bayh, Inga, Scatizzi, Laura, Etter, Michael, Guinsburg, Adrian, Barth, Claudia, Marelli, Cristina, Carioni, Paola, van der Sande, Frank, Kooman, Jeroen P, Liu, Eric, Toffelmire, Ted, Wang, Yuedong, Thijssen, Stephan, Usvyat, Len A, Kotanko, Peter
• Format: Journal Article
• Language: English
• Published: Switzerland 01-01-2015
• Subjects: Aged; Biomarkers; C-Reactive Protein - analysis; Cohort Studies; Cross-Sectional Studies; Female; Humans; Leukocyte Count; Lymphocytes - physiology; Male; Middle Aged; Neutrophils - physiology; Renal Dialysis; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - drug therapy; Reproducibility of Results; Retrospective Studies; Serum Albumin - analysis; Treatment Outcome
• ISSN: 2235-3186
• DOI: 10.1159/000437005

The neutrophil-to-lymphocyte ratio (NLR), defined as the neutrophil count divided by lymphocyte count, is an inexpensive and readily available parameter, which may serve as a surrogate for inflammation markers, such as C-reactive protein (CRP). The aim of this study was to determine the utility of NLR in the prediction of elevated CRP levels in hemodialysis (HD) patients.
We analyzed 43,272 HD patients from 2 distinct cohorts within the Monitoring Dialysis Outcomes research collaboration in whom contemporaneous measurements of neutrophil and lymphocyte counts, serum albumin and CRP levels were available. Logistic regression was used to determine the relationship of trichotomized NLR (<2.5, 2.5-5 and >5.0) and albumin levels (<3.1, 3.1-4.0 and >4.0 g/dl) with elevated CRP levels (>10.0, >20.0 and >30.0 mg/l). Congruence of the prediction models was examined by comparing the regression parameters and by cross-validating each regression equation within the other cohort.
We found that NLR >5.0 vs. <2.5 (cohort 1: OR 2.3; p < 0.0001 and cohort 2: OR 2.0; p < 0.0001) was associated with CRP levels >10.0 mg/l. Stepwise increase in odds ratio for CRP >10.0 mg/l was observed with the combination of high NLR and low albumin levels (NLR >5.0 and albumin <3.1) (cohort 1: OR 7.6; p < 0.0001 and cohort 2: OR 11.9; p < 0.0001). Cross-validation of the 2 regression models revealed a predictive accuracy of 0.68 and 0.69 in the respective cohorts.
This study suggests that NLR could serve as a potential surrogate marker for CRP. Our results may add to diagnostic abilities in settings where CRP is not measured routinely in HD patients. NLR is easy to integrate into daily practice and may be used as a marker of systemic inflammation.