Toxic effects of ionic magnetic fluids in mice

• Published in: Journal of magnetism and magnetic materials Vol. 194; no. 1; pp. 90 - 95
• Main Authors: Lacava, Z.G.M., Azevedo, R.B., Lacava, L.M., Martins, E.V., Garcia, V.A.P., Rébula, C.A., Lemos, A.P.C., Sousa, M.H., Tourinho, F.A., Morais, P.C., Da Silva, M.F.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 1999; Elsevier Science
• Subjects: Biocompatibility; Biocompatible material; Biological and medical sciences; Cells; Cytology; Drug toxicity and drugs side effects treatment; Ferrofluid; Ionic magnetic fluid; Macrophage; Magnetization; Medical sciences; Miscellaneous (drug allergy, mutagens, teratogens...); Morphology; Pharmacology. Drug treatments; Tartrate-based magnetic fluid; Tissue; Toxicity; Van der Waals forces; Ferrofluid; Ionic magnetic fluid; Tartrate-based magnetic fluid; Toxicity; Macrophage; Biocompatible material; Intraperitoneal administration; Leukocyte; Mitosis; Ionic solution; Nanoparticle; Rodentia; Magnetic fluid; Experimental study; Tartrate; Tissue; Vertebrata; Ferrite; Mammalia; Adsorption; Mouse; Animal; Cell cycle; Biocompatibility; Biomaterial; Biological effect; Biomedical engineering; Manganese; Peritoneum
• ISSN: 0304-8853
• DOI: 10.1016/S0304-8853(98)00583-6

Toxicity of ionic and tartrate-based magnetic fluids administered intraperitoneally to mice was investigated through morphological and cytometric alterations and cytogenetic analysis. Both magnetic fluids cause cellular death, mutagenicity and severe inflammatory reactions, being very toxic and thus not biocompatible. Peritoneal cell and tissue studies may provide a useful strategy to investigate the in vivo biological effects of magnetic nanoparticles.