Of mice, flies, and man: the emerging role of polycomb-group genes in human malignant lymphomas

Genes belonging to the Polycomb group (PcG) are responsible for the maintenance of cell identity and are directly involved in epigenetic gene silencing. They perform a vital role in the regulation of embryogenesis but also contribute to various adult processes, including regulation of the cell cycle...

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Bibliographic Details
Published in:	International journal of hematology Vol. 81; no. 4; pp. 281 - 287
Main Author:	Raaphorst, Frank M
Format:	Journal Article
Language:	English
Published:	Japan Springer Nature B.V 01-05-2005
Subjects:	Animals Apoptosis Cell Cycle Diptera - genetics Embryonic Development Gene Silencing Humans Lymphoma, B-Cell - genetics Lymphoma, T-Cell - genetics Mice - genetics Polycomb-Group Proteins Repressor Proteins - genetics
Online Access:	Get full text
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Summary:	Genes belonging to the Polycomb group (PcG) are responsible for the maintenance of cell identity and are directly involved in epigenetic gene silencing. They perform a vital role in the regulation of embryogenesis but also contribute to various adult processes, including regulation of the cell cycle and lymphopoiesis. Experimental model systems have demonstrated that enhanced expression of individual PcG genes, such as Bmi1, results in the development of B-cell and T-cell lymphomas. In humans, a growing body of work has now linked human PcG genes to various hematologic and epithelial cancers. This review focuses on the emerging role of PcG genes in the development of human malignant lymphomas.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0925-5710 1865-3774
DOI:	10.1532/IJH97.05023