Efficient synthesis of novel spiro[indole-3,6′-pyrano[2,3-d][1,3]thiazolo[3,2-a]pyrimidine derivatives through an organobase-catalyzed, three-component reaction

Efficient synthesis of novel spiro[indole-3,6′-pyrano[2,3-d][1,3]thiazolo[3,2-a]pyrimidine derivatives through an organobase-catalyzed, three-component reaction

A fast and convenient protocol for the synthesis of novel spirooxindole derivatives in excellent yields was developed by the three-component reactions of malononitrile, isatin, and 2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-5,7(6H)-dione in the presence of diisopropylethylamine. [Display omitted]

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Bibliographic Details
Published in:Tetrahedron Vol. 71; no. 16; pp. 2458 - 2462
Main Authors: Esmaeili, Abbas Ali, Amini-Ghalandarabad, Saeid, Mesbah, Fariba, Tasmimi, Masoud, Izadyar, Mohammad, Fakhari, Ali Reza, Salimi, Ali Reza
Format: Journal Article
Language:English
Published: Elsevier Ltd 22-04-2015
Subjects:
Malononitrile
Pyranothiazolopyrimidine
Spirooxindole
Three-component reactions
Malononitrile
Spirooxindole
Pyranothiazolopyrimidine
Three-component reactions
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Description
Summary:A fast and convenient protocol for the synthesis of novel spirooxindole derivatives in excellent yields was developed by the three-component reactions of malononitrile, isatin, and 2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-5,7(6H)-dione in the presence of diisopropylethylamine. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2015.01.055