How to Study Boron Biodistribution in Liver Metastases from Colorectal Cancer

• Published in: Journal of chemotherapy (Florence) Vol. 16; no. sup5; pp. 15 - 18
• Main Authors: Roveda, L., Prati, U., Bakeine, J., Trotta, F., Marotta, P., Valsecchi, P., Zonta, A., Nano, R., Facoetti, A., Chiari, P., Barni, S., Pinelli, T., Altieri, S., Braghieri, A., Bruschi, P., Fossati, F., Pedroni, P.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01-11-2004
• Subjects: Animals; Boron - pharmacokinetics; Boron Neutron Capture Therapy; Colorectal Neoplasms - pathology; liver metastasis; Liver Neoplasms - radiotherapy; Liver Neoplasms - secondary; Male; Rats; Tissue Distribution
• ISSN: 1120-009X; 1973-9478
• DOI: 10.1080/1120009X.2004.11782375

The purpose of this study was to evaluate boron distribution for a safe and effective BNCT (Boron Neutron Capture Therapy) of liver metastases. Samples both from healthy and tumour liver parenchyma were analysed, after i.v. boron administration, by: a particles counting under neutron irradiation; morphological analysis by standard haematoxylin-eosin staining; neutron autoradiography. Our method was unaffected by the cytological heterogeneity inside tumour nodules; it demonstrated selective boron distribution in tumour tissue and predicted estimated mean therapeutic doses in tumour and safety doses in healthy tissue. The time interval for efficient BNCT was 2 to 4 hours after i.v. boron administration.