Preparation of chitosan derivative with polyethylene glycol side chains for porous structure without specific processing technique

• Published in: International journal of biological macromolecules Vol. 38; no. 3; pp. 191 - 196
• Main Authors: Huang, Meifang, Liu, Li, Zhang, Guobin, Yuan, Guangbi, Fang, Yue’e
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30-05-2006
• Subjects: Biocompatible Materials - chemistry; Chitosan; Chitosan - chemistry; Graft copolymers; Hot Temperature; Macromolecular Substances - chemistry; Micelles; Microscopy, Electron, Scanning; Models, Chemical; Polyethylene glycol; Polyethylene Glycols - chemistry; Polymers - chemistry; Porous structure; Spectrometry, Fluorescence; Temperature; X-Ray Diffraction; Porous structure; Graft copolymers; Chitosan; Polyethylene glycol
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2006.02.008

The graft copolymer, chitosan-g-polyethylene glycol (PEG), was prepared through graft polymerization of PEG chains to chitosan due to the esterification reaction between PEG and 6-
O-succinate-
N-phthaloyl-chitosan (PHCSSA). The graft copolymer with porous structure was observed from scanning electron micrographs. It is a potential method to combine chitosan with the hydrophilic synthetic polymers. The graft reaction was carried out in homogeneous system and yielded copolymers with high grafting content. FTIR, NMR, XRD, DSC, spectrofluorophotometer and SEM were detected to characterize the copolymer.