Lesion detection performance: comparative analysis of low-dose CT data of the chest on two hybrid imaging systems

• Published in: Journal of nuclear medicine technology Vol. 43; no. 1; pp. 47 - 52
• Main Authors: Jessop, Maryam, Thompson, John D, Coward, Joanne, Sanderud, Audun, Jorge, José, de Groot, Martijn, Lança, Luís, Hogg, Peter
• Format: Journal Article
• Language: English
• Published: United States 01-03-2015
• Subjects: Humans; Image Processing, Computer-Assisted; Incidental Findings; Myocardial Perfusion Imaging; Neoplasms - diagnostic imaging; Phantoms, Imaging; Radiation Dosage; Radiography, Thoracic; ROC Curve; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; low-dose CT; incidental findings; CTAC; JAFROC; observer performance
• ISSN: 0091-4916; 1535-5675
• DOI: 10.2967/jnmt.114.147447

Incidental findings on low-dose CT images obtained during hybrid imaging are an increasing phenomenon as CT technology advances. Understanding the diagnostic value of incidental findings along with the technical limitations is important when reporting image results and recommending follow-up, which may result in an additional radiation dose from further diagnostic imaging and an increase in patient anxiety. This study assessed lesions incidentally detected on CT images acquired for attenuation correction on two SPECT/CT systems.
An anthropomorphic chest phantom containing simulated lesions of varying size and density was imaged on an Infinia Hawkeye 4 and a Symbia T6 using the low-dose CT settings applied for attenuation correction acquisitions in myocardial perfusion imaging. Twenty-two interpreters assessed 46 images from each SPECT/CT system (15 normal images and 31 abnormal images; 41 lesions). Data were evaluated using a jackknife alternative free-response receiver-operating-characteristic analysis (JAFROC).
JAFROC analysis showed a significant difference (P < 0.0001) in lesion detection, with the figures of merit being 0.599 (95% confidence interval, 0.568, 0.631) and 0.810 (95% confidence interval, 0.781, 0.839) for the Infinia Hawkeye 4 and Symbia T6, respectively. Lesion detection on the Infinia Hawkeye 4 was generally limited to larger, higher-density lesions. The Symbia T6 allowed improved detection rates for midsized lesions and some lower-density lesions. However, interpreters struggled to detect small (5 mm) lesions on both image sets, irrespective of density.
Lesion detection is more reliable on low-dose CT images from the Symbia T6 than from the Infinia Hawkeye 4. This phantom-based study gives an indication of potential lesion detection in the clinical context as shown by two commonly used SPECT/CT systems, which may assist the clinician in determining whether further diagnostic imaging is justified.