Increased serum interleukin 22 levels in patients with axial spondyloarthritis

• Published in: Expert review of clinical immunology Vol. 19; no. 1; p. 123
• Main Authors: Slouma, Maroua, Kharrat, Lobna, Tezegdenti, Aymen, Metoui, Leila, Dhahri, Rim, Ghazouani, Ezzeddine, Cheour, Elhem, Gharsallah, Imen, Louzir, Bassem
• Format: Journal Article
• Language: English
• Published: England 02-01-2023
• Subjects: Axial Spondyloarthritis; Case-Control Studies; Cytokines; Humans; Interleukin-22; Interleukins; Low Back Pain; Spondylarthritis; Spondylitis, Ankylosing; Ankylosing Spondylitis; cytokine; nonspecific low back pain; interleukin-22; axial spondyloarthritis
• ISSN: 1744-8409
• DOI: 10.1080/1744666X.2023.2142563

The role of IL-22 in radiographic axial spondyloarthritis is not fully elucidated. Thus, there is a need for new insights into this cytokine in this disease. We aimed to compare interleukin (IL)-22 level between spondyloarthritis, nonspecific-low back pain patients, and pain-free controls, and to evaluate associations between this cytokine and spondyloarthritis characteristics.
We conducted a case-control study including 62 patients with radiographic axial spondyloarthritis (G1), 46 with nonspecific low back pain (G2), and 42 healthy volunteers (G3). IL-22 was measured using Enzyme-linked immunosorbent assay. We evaluate disease activity and structural damage of spondyloarthritis.
IL-22 level was higher in G1 than in G2 and G3 (38±40 versus14.42±8.17 versus14.3±18.67 pg/mL, p<0.01). IL-22 discriminated patients in G1 from G2 with a cutoff of 22.28pg/mL (Sensitivity: 62.9%, Specificity: 97.8%, area under the curve (AUC): 0.808). IL-22 cutoff of 19.27pg/mL discriminated patients in G1 from G3 (Sensitivity: 67%, Specificity: 94.3%, AUC: 0.855). No associations were found between IL-22 levels and disease activity and structural damage.
Our study showed that IL-22 level was higher in radiographic axial spondyloarthritis patients compared to controls. It was also able to differentiate G1 patients from G2 and G3. This finding suggests that the IL-22 pathway showed to play a pathological role in spondyloarthritis.